Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery
원저

이명 치료에서 항우울제의 효과

최성원1, 이현민2, 김동원1, 정희정3,*
Sung-Won Choi1, Hyun-Min Lee2, Dongwon Kim1, Hee-Jeong Jeong3,*
1부산대학교 의과대학 부산대학교병원 이비인후과학교실
2부산대학교 의과대학 양산부산대학교병원 이비인후과학교실
3부산대학교 의과대학 부산대학교병원 정신건강의학과학교실
1Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine, Pusan National University Hospital, Busan
2Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine, Yangsan Pusan National University Hospital, Yangsan
3Department of Psychiatry, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea
*교신저자: 정희정, 49241 부산광역시 서구 구덕로 179 부산대학교 의과대학 정신건강의학교실 전화: (051) 240-7301·전송: (051) 248-3648·E-mail:jhjdoc@naver.com

© Copyright 2018 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Mar 12, 2018; Revised: Apr 03, 2018; Accepted: Apr 26, 2018

Published Online: May 31, 2020

ABSTRACT

Background and Objectives: Tinnitus is one of the common symptom that designate a significant comorbidity with anxiety and depression. Among antidepressants, a selective serotonin reuptake inhibitor (SSRI) is frequently used in pharmacological protocols for the management of tinnitus. This study aims to verify the effect of the SSRI on the patients with tinnitus. Subjects and Methods: Thirty-eight patients with chronic tinnitus, who visited in Pusan National University Hospital from Jan 2015 to December 2016 were investigated prospectively. Pretreatment and posttreatment by taking SSRI Visual analogue scale (VAS) measurements of tinnitus loudness (intensity), duration, annoyance, impact of life, and Tinnitus Handicap Inventory (THI) and its subcategory (functional, emotional, catastrophic) were evaluated and compared. Results: Four subjects were dropped out due to intolerability. VAS measurements such as annoyance, impact of life were improved significantly after treatment. In THI score, not only total score but also subcategory scores were got better, which had statistical significance. Conclusions: Our results show that SSRI could positive effect on chronic tinnitus patients with considerable tolerability. But it might be necessary the evidence-based approach such as double blind randomized controlled trial to clarify the effect of SSRI on tinnitus. (J Clinical Otolaryngol 2018;29:36-41)

Keywords: 이명; 항우울제; 치료; 세로토닌 재흡수 억제제
Keywords: Tinnitus; Depression; Treatment; Selective serotonin reuptake inhibitor