Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery
원저

쇼그렌 증후군 환자에서 작은 침샘 조직검사의 진단적 효용성

강보성1, 김재욱1,*
Bo sung Kang1, Jae wook Kim1,*
1순천향대학교 의과대학 이비인후과학교실
1Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Seoul, Korea
*교신저자: 김재욱, 04401 서울 용산구 대사관로 59 순천향대학교 의과대학 서울병원 이비인후과 학교실 전화: (02) 709-9360·전송: (02) 709-9134 E-mail: entkjw@gmail.com

© Copyright 2015 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Aug 06, 2015; Revised: Oct 27, 2015; Accepted: Nov 13, 2015

Published Online: May 31, 2020

ABSTRACT

Background : Sjögren’s syndrome is difficult to diagnose. Because several tools for exact diagnosis have been made over the decades. However none of them is both sensitive and specific. American College of Rheumatology (ACR) issued new diagnostic criteria based on only three objective tests in 2012. These are immunosero- logic test, minor salivary gland biopsy, ocular staining test. We analyzed diagnostic effectiveness of minor salivary gland biopsy in suggesting Sjögren’s syndrome patients based on ACR guideline. Methods: We analyze 41 patients who suggesting Sjögren’s syndrome retrospectively about Immunoserologic results, minor salivary gland biopsy results, ocular staining test. Sensitivity and specificity of minor salivary gland biopsy was obtained. Results: Minor salivary gland biopsy sensitivity was 70.8% and specificity, 100%, positive predictive value, 100%, negative predictive value, 70.8%. No salivary gland biopsy complication was noted in 41 patients. Conclusions: Minor salivary gland biopsy is objective test and keyword method for Sjögren’s syndrome final diagnosis. High specificity can help physician to exclude normal people from Sjögren’s syndrome patients. Due to relatively invasive procedure and low sensitivity, this procedure could be recommended to last step for final diagnosis. (J Clinical Otolaryngol 2015;26:230–235)

Keywords: 쇼그렌 증후군; 작은 침샘 조직검사
Keywords: Sjogren’s syndrome; Minor salivary gland biopsy