Journal of Clinical Otolaryngology Head and Neck Surgery

The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery

J Clin Otolaryngol Head Neck Surg 2014; 25(1):37-43

pISSN: 1225-0244, eISSN: 2713-833X

DOI: https://doi.org/10.35420/jcohns.2014.25.1.37

원저

한국인의 인후두암과 Helicobacter Pylori균의 상관관계에 대한 고찰

조재현¹, 한상윤¹, 장호준¹, 구민본¹, 안동빈², 여창기¹^,^*

Association between Helicobacter Pylori Infection and Laryngopharyngeal Squamous Cell Carcinoma in Korean Population

Jae Hyun Cho¹, Sang Yoon Han¹, Ho Joon Jang¹, Min Bon Koo¹, Dongbin Ahn², Chang Ki Yeo¹^,^*

¹계명대학교 의과대학 이비인후-두경부외과학교실

²경북대학교 의과대학 이비인후-두경부외과학교실

¹Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Keimyung University, Daegu, Korea

²Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, Korea

^*교신저자: 여창기，700-712 대구광역시 중구 달성로 56 계명대학교 의과대학 이비 인후-두경부외과학교실 전화: (053) 250-7757· 전송: (053) 256-0325 E-mail： ckyeo@dsmc.or.kr

© Copyright 2014 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Jan 21, 2014; Revised: Mar 21, 2014; Accepted: May 22, 2014

Published Online: May 31, 2020

ABSTRACT

Background and Objectives: Several studies have implicated Helicobacter pylori as a risk factor in laryngopah- ryngeal cancer, but other studies disagree. We investigate the possibility that H. pylori as a cause of squamous cell carcinoma of pharynx and larynx in Korean population. Subjects and Methods: A total of 30 patients with laryn-gopharyngeal cancer and 41 control subjects with benign layngeal disease. Campylobacter-Like Organism (CLO) test and Cresyl-Violet stain was performed on 71 patients to identify H. pylori infection. Tissue samples were collected from tumoral tissue and benign laryngeal diseases and mucosa at posterior arytenoid area adjacent to esophagus. Results:H. pylori was detected in 5 (16.7%) of the 30 patients with laryngopharyngeal cancer, 5 (12.2%) of the 41 patients with benign laryngeal diseases (p=0.733). The correlation between H. pylori infection and la-ryngopharyngeal cancer was no significant difference [OR=2.73, 95% CI (0.30-24.99)]. Conclusions: Our study shows H. pylori infection of laryngopharyngeal mucosa is not related to the possible etiologic association squamous cell carcinoma of larynx and pharynx in Korean population. (J Clinical Otolaryngol 2014;25:37-43)

Keywords: 헬리코박터균; 인두암; 후두암

Keywords: Helicobacter pylori; Laryngeal cnacer; Pharyngeal cancer