Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery

Carcinoma Ex Pleomorphic Adenoma(CXPA)의 임상적 예후 인자

이윤세1, 현상민2, 임길채3, 최승호2, 김상윤2, 남순열2,*
Yoon Se Lee1, Sang Min Hyun2, Gil Chai Lim3, Seung-Ho Choi2, Sang Yoon Kim2, Soon Yuhl Nam2,*
1부산대학교 의학전문대학원 양산부산대학교병원 이비인후과학교실
2울산대학교 의과대학 서울아산병원 이비인후과학교실
3제주대학교 의학전문대학원 제주대학교병원 이비인후과학교실
1Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Pusan National University, Yangsan Hospital, Yangsan, Korea
2Department of Otolaryngology, College of Medicine, University of Ulsan, Ansan Medical Center, Seoul, Korea
3Department of Otolaryngology, School of Medicine, Jeju National University, Jeju Hospital, Jeju, Korea
*교신저자: 남순열, 138-736 서울 송파구 풍납2동 388-1 울산대학교 의과대학 서울아산병원 이비인후과학교실 전화: (02) 3010—3710· 전송: (02) 489-2773· E-mail:

© Copyright 2009 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Mar 11, 2009; Revised: Apr 14, 2009; Accepted: Apr 22, 2009

Published Online: May 31, 2020


Background and Objectives: Carcinoma ex plemorphic adenoma (CXPA) originated from the salivary glands is rare but aggressive. It is known to be a high-grade carcinoma, frequently showing poor prognosis due to disease-related death and metastasis. Materials and Methods: We reviewed medical charts of patients who were diagnosed to have CXPA and received treatment fom January, 1990 to July, 2008 at Asan medical center. Results: Thirty one patients (male: female=20: 11) underwent surgery and/or adjuvant radiation therapy. The parotid gland was the most common site (74%). The tumors in the parotid were resected in the method of simple excision (4%), superficial parotidectomy (26%) or total parotidectomy with or without neck dissection (70%). Five year overall survival rate was 84.07%. According to site or treatment method in parotid gland originated tumor, there was no significant difference in survival rate and local control rate. Postoperative pathologic status of margin was the only factor influencing prognosis (p=0.04). Conclusion: Proper excision is a mainstay in the treatment of CXPA and preoperative evaluation of tumor extent is important. (J Clinical Otolaryngol 2009; 20:49–54)

Keywords: 침샘암; 다형성 기시암종
Keywords: Salivary gland neoplasm; Pleomorphic adenoma; Malignant mixed tumor