Journal of Clinical Otolaryngology Head and Neck Surgery
The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery
원저

타액선 종양에서 COX-2의 발현에 관한 연구

금효섭1, 이용섭1, 김경래1, 박철원1, 태경1,*, 백승삼2
Hyo Sub Keum1, Yong Seop Lee1, Kyung Rae Kim1, Chul Won Park1, Kyung Tae1,*, Seung Sam Paik2
1한양대학교 의과대학 이비인후과학교실
2병리학교실
1Department of Otolaryngology, College of Medicine, Hanyang University, Seoul, Korea
2Pathology, College of Medicine, Hanyang University, Seoul, Korea
*교신저자: 태 경, 471-701 경기도 구리시 교문동 249-1 한양대학교 의과대학 이비인후과학교실 전화: (031) 560-2363·전송: (031) 566-4884 E-mail: kytae@hanyang.ac.kr

© Copyright 2006 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Mar 03, 2006; Accepted: May 23, 2006

Published Online: May 31, 2020

ABSTRACT

Objectives: Cyclooxygenase (COX) is the rate limiting enzyme in the conversion of arachidonic acid to prostaglandins. To date, two isoforms of COX, COX-1 and COX-2, have been identified. Especially, elavated COX-2 expression has been shown to occur in several malignancies. In the head and neck, COX-2 has been reported to be up-regulated in squamous cell carcinomas. The aim of this study is to evaluate the significance of expression of COX-2 in benign and malignant salivary gland tumors. Materials and Methods: Immunohistochemical analysis was used to detect expression of COX-2 in paraffin-embedded samples from 63 benign and 51 malignant salivary gland tumors. Results were analyzed between benign and malignant tumors and compared with the clinical parameters such as stage and recurrence in malignant tumors. Results: COX-2 overexpression was detected in 23.8% of the benign salivary gland tumors and 33.3% of the malignant salivary gland tumors. But there was no statistical significance. According to histologic classification in benign Salivary gland tumor, COX-2 overexpression of COX-2 was detected in 32.5% of pleomorphic adenoma and in 10.5% of warthin’s tumor. In malignant salivary gland tumor, COX-2 overexpression was detected in 33.3% of mucoepidermoid carcinoma. And in 26.6% of adenoid cystic carcinoma. But there were no statistical significance. 31 % of male were positive for COX-2 and 25% of female were positive for COX-2. Male showed slightly higher expression rate, but there was no statistical significance. Conclusions: COX-2 overexpression is not associated with the progression of malignant salivary gland tumors. But there are many reports that COX- 2 is associated with carcinogenesis in other malignant tumors. So further studies with large number of patient will be needed. (J Clinical Otolaryngol 2006;17:66–72)

Keywords: 타액선 종양; cyclooxygenase-2
Keywords: Salivary gland tumor; Cyclooxygenase-2