Journal of Clinical Otolaryngology Head and Neck Surgery

The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery

J Clin Otolaryngol Head Neck Surg 2001; 12(1):83-88

pISSN: 1225-0244, eISSN: 2713-833X

DOI: https://doi.org/10.35420/jcohns.2001.12.1.83

증례

혈액식작용 증후군을 동반한 구인두의 T/NK세포 림프종

전은주¹, 최영철¹, 박용수¹^,^*, 김경미²

A Case of Oropharyngeal T/NK-Cell Lymphoma with Hemophagocytic Syndrome

Eun-ju Jeon¹, Young-Chul Choi¹, Yong-Soo Park¹^,^*, Kyoung-Mee Kim²

¹가톨릭대학교 의과대학 이비인후과학교실

²임상병리학교실

¹Department of Otolaryngology-Head and Neck Surgery the Catholic University of Korea, Seoul, Korea

²Clinical Pathology, College of Medicine, the Catholic University of Korea, Seoul, Korea

^*교신저자: 박용수, 403-720 인천광역시 부평구 부평6동 665 가톨릭대학교 의과대학 이비인후과학교실 전화: (032) 510-5526·전송: (032) 510-5821 E-mail: parkent@olmh.cuk.ac.kr

© Copyright 2001 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Dec 08, 2000; Accepted: May 27, 2001

Published Online: May 31, 2020

ABSTRACT

T/NK-cell lymphoma (TNKL) is a subtype of angiocentric T-cell lymphoma showing the characteristics of biphenotype of T-cell and NK-cell, frequent association with Epstein-Barr virus (EBV), and poor clinical course. It usually develops in nasal cavity, paranasal sinus, and nasopharynx. Hemophagocytotic syndrome is a histiocytic proliferation associated with phagocytosis of the hemopoietic elements resulting in fever, profound pancytopenia, hepatosplenomegaly, lymphadenopathy, and coagulopathy. It is considered as a negative prognostic factor for hematologic neoplasms. Epstein-Barr virus infection is considered as pathogenic factor for hemophagocytotic syndrome. We experienced a case of EBV-infected oropharyngeal lymphoma of T/NK-cell lymphoma associated with hemophagocytotic syndrome, which was confirmed by immunohistochemical study, in situ hybridization, and bone marrow biopsy. We report this case with brief review of literatures. (J Clinical Otolaryngol 2001;12:83-88)

Keywords: 림프종; T-세포 림프종; EB 바이러스 감염; 혈액식작용 증후군

Keywords: Lymphoma; T-cell lymphoma; EB virus infection; Hemophagocytic syndrome