Table 1. Reported cases of melanotic oncocytic metaplasia of the nasopharynx

Case	Sex/ age	Site	Symptom	Endoscopic finding	Number	Clinical impression	Smoking history
11	M/67	ETO	Serous otitis media	2 mm brown nodule	Single	Nasopharyngeal carcinoma	Unknown
21	M/63	ETO	Tinnitus	2 mm brown nodule	Single	Nasopharyngeal carcinoma	Unknown
32	M/69	NPx	None	Small black lesions with slightly elevation	Multiple	Not documented	Unknown
43	M/70	ETO	Tinnitus	1-2 mm brown nodules	Multiple	Nevus	Unknown
54	M/64	ETO / NC / Suprapharynx	Discomfort of the throat	Small, flat elevations with brown discoloration up to a few millimeters	Multiple	Malignant tumor	Unknown
65	M/79	ETO	Hearing loss / Otorrhea / Otalgia	A pigmented lesion	Single	Not documented	Unknown
76	M/62	ETO	Discomfort of the ear	5 mm black nodule & small spots with black discoloration	Multiple	Melanoma	Unknown
87	M/80	NC / Pharynx	Hoarseness	Lesions with a few millimeters in size, brown to black in color	Multiple	Melanoma	Smoker (25PY)
97	M/69	ETO	Rhinorrhea	Lesions with a few millimeters in size, brown to black in color	Single	Melanoma	Smoker (120PY)
107	M/74	Suprapharynx	Epistaxis	Lesions with a few millimeters in size, brown to black in color	Single	Tumor	Unknown
117	F/74	ETO	Discomfort of the throat	Lesions with a few millimeters in size, brown to black in color	Multiple	Melanoma	Unknown
127	M/68	NPx	None	Lesions with a few millimeters in size, brown to black in color	Single	Tumor	Unknown
137	M/56	ETO	Hemoptysis	Lesions with a few millimeters in size, brown to black in color	Single	Not documented	Unknown
147	M/63	ETO	Epistaxis	Lesions with a few millimeters in size, brown to black in color	Single	Melanoma	Unknown
158	M/ND	NPx	None	Pigmented lesions	Multiple	Not documented	Unknown
169	M/58	NPx	Epistaxis	Small, irregular, black-pigmented lesions	Multiple	Not documented	Unknown
1710	M/73	TT	Nasal obstruction / Chill	Black nodules measuring several millimeters	Multiple	Melanoma / Hemangioma	Non-smoker
1811	M/72	TT	Headache / Hearing loss	Dark blue colored mucosal lesions	Multiple	Melanotic dysplasia	Smoker (100PY)
1911	M/71	TT / Soft palate	Hoarseness	Black mucosal lesions	Multiple	Nasopharyngeal pigmented lesion	Smoker (40PY)
2011	M/51	TT	Tongue pain	Dark colored spots	Multiple	Melanotic oncocytic metalplasia of nasopharynx	Unknown
2112	M/63	NPx	Epistaxis	Black nodules up to several millimeters	Multiple	Melanosis / Melanoma	Smoker (80PY)
2213	M/57	TT	None	2-3 mm flat, elevated lesions with brown to black discoloration	Multiple	Melanoma	Smoker (60PY)
2314	M/60s	TT	None	Black nevus-like lesion	Single	Not documented	Unknown
2415	F/70	ETO	None	2 mm black nodules	Multiple	Melanosis	Smoker (12.5PY)
2515	F/61	ETO	Hoarseness	2 mm black nodule	Single	Melanoma	Smoker (46PY)
2615	M/74	NPx	Hoarseness	2 mm black nodules	Multiple	Melanoma	Smoker (50PY)
2716	M/57	NPx	Nasal obstruction	Flat lesion with pigmentation	Single	Not documented	Smoker (ND)
2816	M/61	NPx	Neck mass	Mass without pigmentation	Single	Not documented	Smoker (ND)
2916	M/69	NPx	Rhinorrhea	Flat lesion with pigmentation	Multiple	Not documented	Smoker (ND)
3016	M/56	ETO	Epistaxis	Flat lesion with pigmentation	Single	Not documented	Smoker (ND)
3116	M/58	NPx	Cranial nerve VII palsy	Flat lesion with pigmentation	Single	Not documented	Smoker (ND)
3216	M/52	ETO	Tinnitus	Flat lesion with pigmentation	Multiple	Not documented	Smoker (ND)
3316	F/77	NPx	Hoarseness	Nodule with pigmentation	Single	Not documented	Smoker (ND)
3416	M/59	NPx	Nasal obstruction	Flat spot with pigmentation	Single	Not documented	Smoker (ND)
3516	M/59	ETO	Tinnitus	Nodule without pigmentation	Single	Not documented	Smoker (ND)
3617	M/75	ETO	Epistaxis / Rhinorrhea / Cough / Sputum	Brown nodules	Multiple	Nevus / Melanoma	Smoker (75PY)
38 (present)	M/76	ETO	Globus pharyngeus	Cystic mass	Single	Cystic mass	Smoker (6PY)

ETO: Eustachian tube opening, NPx: nasopharynx, NC: nasal cavity, TT: torus tubarius, PY: pack-year, ND: not documented, CEA: carcinoembryonic antigen, F: female, M: male.