비용에서의 Bcl-2, Bax, Fas의 발현 양상

Background and Objectives: Nasal polyp is non-neoplastic, chronic inflammatory disease of the nasal mucosa. Their formation may be associated with allergy or inflammation. Bcl-2 is known as anti-apoptotic gene, whereas Bax and Fas are known as pro-apoptotic genes. To illustrate the role of the Bcl-2, Bax and Fas in the pathogenesis of nasal polyp, we investigated expressive pattern of the Bcl-2, Bax and Fas in nasal polyp. Materials and Methods: The study samples were obtained after surgical removal of 19 cases of nasal polyp and 13 cases of normal nasal mucosa in the inferior turbinate as a control. The Bcl-2, Bax and Fas expressions were assessed by immunohistochemical staining. Result: The Bcl-2, Bax and Fas were expressed at seromucinous gland and cytoplasm of respiratory epithelium of nasal polyp and normal control. Only the Bcl-2 expression of nasal polyp was significantly decreased compared to normal control (p=0.0001). Conclusion: This study suggests that apoptosis inhibition by the Bcl-2 may be not related to the formation of nasal polyp. (J Clinical Otolaryngol 2003;14:76–80)