소아 만성 부비동염환자의 아데노이드에서 Mast Cell의 분포 및 탈과립

Background and Objectives: The purpose of this study is to evaluate the relationship between immunologic inflammatory reaction and rhinosinusitis by examine the adenoid mast cell count and its degranulation in pediatric rhinosinusitis patients. Materials and Method: The distribution of mast cells in the adenoidectomy specimens of 36 children with enlarged adenoid without allergy history was studied. Eighteen patients had rhinosinusitis and remaining 18 is control group without evidence of rhinosinusitis. Mast cell were identified on the basis of the metachromatic staining of their cytoplasmic granule with toluidine blue. Age distribution of rhinosinusitis group ranged from 3 years 10 months to 11years 6 months (mean: 6 years 10 months). And that of control group is 3years 11 months to 15 years (mean 6 years 10 months). Results: Patient with rhinosinusitis had 22.4 cells per a high power field (×400) and 10.2 cells in control group. Degranulation cell count is 10.5 compaired to 2.88 in control group. Degranulation analysis confirmed the difference between the two group is significant (p<0.001). Conclusion: In pediatric rhinosinusitis, adenoid mast cell and degranulated cell are much denser than control group. Degranulation of adenoid mast cell release histamine and other inflammatory mediators which might play some role in pathogenesis and chronicity of pediatric rhinosinusitis. (J Clinical Otolaryngol 2001;12:234-239)